Welcome to the Crystal Journal of Medicine & Healthcare (CJM&H), a leading platform dedicated to advancing medical science and healthcare practices. CJM&H publishes high-quality, peer-reviewed research that bridges clinical practice with scientific innovation, aiming to improve global health outcomes.
Welcome to the Crystal Journal of Medicine & Healthcare (CJM&H), a leading platform dedicated to advancing medical science and healthcare practices. CJM&H publishes high-quality, peer-reviewed research that bridges clinical practice with scientific innovation, aiming to improve global health outcomes.
CJM&H focuses on disseminating impactful research and insights into medicine and healthcare, fostering advancements in clinical practice, patient care, and medical technology.
Core Areas of Focus:
Our Vision
CJM&H strives to be a global hub for knowledge exchange, promoting innovation and evidence-based practices in medicine and healthcare.
Why Publish with Us?
Submission Guidelines
CJM&H accepts research articles, reviews, case studies, and commentaries. Please refer to our submission guidelines online for more details.
Affiliation: Senior Hair Consultant High-density-hair-transplants Greece, United Kingdom.
Research Interest: Hair Restoration and Hair Drug Therapy.
Affiliation: Department of Philology, University of Almeria, Spain.
Research Interest: Medieval Arabic Science, History of Medicine, Philological Studies, Humanities.
Affiliation: Professor of Department of Chemistry, Alexandru Ioan Cuza University, Romania.
Research Interest: Medicinal Chemistry and Drug Design, Chemical Engineering, Modern Approaches in Drug Designing, Pharmaceutical Toxicology.
Affiliation: Department of Neuropsychological, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Research Interest: Clinical Neuropsychology, Coronary Artery Bypass Surgery, Cognition Disorders, Heart Failure, Cardiac Surgery, Cognitive Neuropsychology, Cognitive Neuroscience, Memory, Executive Function, Cognitive Psychology.
Affiliation: "Alexandru Ioan Cuza" University of Iasi, Faculty of Chemistry, Romania.
Research Interest: Organic Synthesis, Synthetic Drugs, Drug Design and Development, Cyclophanes, Flavonoids, Sulfur Compounds.
Affiliation: Clinical Director of Internal Medicine, Military Hospital Ulm, Germany.
Research Interest: Internal Medicine, Cardiology, Rehabilitation, Emergency Medicine.
Affiliation: University of Calabria, Arcavacata – Rende, Italy.
Research Interest: Management, Public Administration, Accountancy, Health Management.
Authors:
Mohammad Ahmad Ahmad Odah*
Published Date: May 08, 2025
Cite: Odah MAA. Photosynthetic reprogramming enhancing carbon fixation in crops through synthetic biology. Crystal J Med Healthc. 2025;1(1): 01-10.
Abstract
Background: Photosynthesis is the foundation of plant productivity, yet its natural efficiency remains limited, with most staple crops operating under the suboptimal C3 pathway. Enhancing carbon fixation efficiency is a major goal in agricultural biotechnology, especially in the face of climate change and increasing food demands. Synthetic biology offers innovative strategies to reprogram photosynthesis, optimize RuBisCO function, and introduce synthetic carbon assimilation pathways.
Objective: This review explores the latest advancements in synthetic biology applied to photosynthetic reprogramming. It highlights the potential of genetic engineering to enhance carbon fixation, reduce photorespiration losses, and develop highyield, climate-resilient crops.
Methods: A comprehensive literature review was conducted, analyzing recent breakthroughs in RuBisCO optimization, synthetic carbon fixation cycles, and chloroplast genome engineering. Studies on engineered carbon-concentrating mechanisms (CCMs) and artificial CO₂ assimilation pathways were evaluated for their potential applications in agriculture.
Results: Synthetic biology approaches have demonstrated significant improvements in photosynthetic efficiency. Directed evolution has optimized RuBisCO activity, while the integration of bacterial and algal CCMs into C3 plants has increased CO₂ fixation rates. Additionally, synthetic pathways like the CETCH cycle show promise in surpassing the Calvin cycle’s efficiency.
Conclusion: The integration of synthetic biology into photosynthesis enhancement presents a transformative solution to improving crop productivity and climate resilience. While significant progress has been made, challenges remain in scaling these innovations to commercial agriculture. Future research should focus on refining metabolic engineering strategies, addressing regulatory concerns, and ensuring field applicability to maximize the impact of synthetic photosynthesis.
Keywords
Synthetic Biology, Photosynthetic Reprogramming, Carbon Fixation, RuBisCO Optimization, Climate-Resilient Crops, Metabolic Engineering
Authors: Mohammad Ahmad Ahmad Odah*
Published Date: April 30, 2025
Cite: Odah MAA. Mitochondrial epitranscriptomics: The role of RNA modifications in cellular energy regulation and aging. Crystal J Med Healthc. 2025;1(1): 01-08.
Abstract
Background: Mitochondria play a crucial role in cellular metabolism and energy production. While traditionally studied through nuclear and mitochondrial DNA regulation, recent research highlights the significance of post-transcriptional modifications in mitochondrial RNA (mtRNA). These modifications influence mitochondrial gene expression, energy balance, and aging. Understanding mitochondrial epitranscriptomics—specifically modifications like N6-methyladenosine (m6A), pseudouridylation, and 5-methylcytosine (m5C)—is essential for uncovering their impact on cellular function and disease.
Objective: This review aims to explore the emerging field of mitochondrial epitranscriptomics, analyzing key RNA modifications, their roles in oxidative phosphorylation (OXPHOS) and reactive oxygen species (ROS) regulation, and their implications in aging and age-related diseases. Additionally, we discuss advanced methodologies for studying these modifications and potential therapeutic strategies for mitochondrial dysfunction.
Conclusion: Mitochondrial RNA modifications represent a critical layer of gene regulation affecting cellular energy homeostasis and aging. Their dysregulation is associated with metabolic disorders, neurodegenerative diseases, and cellular senescence. Advances in RNA sequencing and epitranscriptomic research highlight the potential for therapeutic interventions targeting mitochondrial RNA modifications to mitigate mitochondrial dysfunction and promote longevity. A deeper understanding of these modifications could pave the way for novel approaches to treating age-related diseases and enhancing healthy aging.
Keywords
Mitochondrial Epitranscriptomics, RNA Modifications, Aging, Oxidative Phosphorylation, m6A, Pseudouridylation, m5C, Neurodegeneration, Metabolic Disorders, Longevity
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General Guidelines
Manuscript Preparation
Authors must ensure their manuscript is well-organized and follows the structure outlined below:
Format
Structure
Manuscripts must be arranged in the following order:
Title Page
Abstract
Introduction
Headings, Subheadings, and Super Subheadings
Materials and Methods
Results/Observations
Discussion
Acknowledgments
References
Books
Journal Articles
Conference Proceedings
Websites
Book Chapters
Tables
Figures and Legends
Submission Process
Funding Statement
Fee Structure
By adhering to these guidelines, authors can ensure a smooth and efficient submission process. Thank you for contributing to the Crystal Journal of Medical Research, and for advancing the global pursuit of sustainability!
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