Crystal Journal of Medicine & Healthcare

Journal Home

Welcome to the Crystal Journal of Medicine & Healthcare (CJM&H), a leading platform dedicated to advancing medical science and healthcare practices. CJM&H publishes high-quality, peer-reviewed research that bridges clinical practice with scientific innovation, aiming to improve global health outcomes.

Journal Home

Welcome to the Crystal Journal of Medicine & Healthcare (CJM&H), a leading platform dedicated to advancing medical science and healthcare practices. CJM&H publishes high-quality, peer-reviewed research that bridges clinical practice with scientific innovation, aiming to improve global health outcomes.

Journal Aims and Scope

CJM&H focuses on disseminating impactful research and insights into medicine and healthcare, fostering advancements in clinical practice, patient care, and medical technology.
Core Areas of Focus:

  • Clinical Medicine:
    • Advances in diagnosis and treatment.
    • Clinical trials and outcomes research.
    • Personalized and precision medicine.
  • Healthcare Systems:
    • Health policy and management.
    • Innovations in healthcare delivery and quality improvement.
    • Telemedicine and digital health.
  • Interdisciplinary Research:
    • Medical informatics and big data analytics.
    • Integration of artificial intelligence in medicine.
    • Public health and epidemiological studies.

 

Our Vision

CJM&H strives to be a global hub for knowledge exchange, promoting innovation and evidence-based practices in medicine and healthcare.

 Why Publish with Us?

  • Rigorous Peer Review: Ensures accuracy and relevance in all published work.
  • Global Accessibility: Open-access model enhances visibility and impact.
  • Fast Publication: Prioritizing timely dissemination of important findings.
  • Renowned Editorial Board: Led by experts in medicine and healthcare.

 Submission Guidelines

CJM&H accepts research articles, reviews, case studies, and commentaries. Please refer to our submission guidelines online for more details.

Editorial Board Members
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Dr. Malcolm Mendelsohn

Affiliation: Senior Hair Consultant High-density-hair-transplants Greece, United Kingdom.
Research Interest: Hair Restoration and Hair Drug Therapy.

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Prof. Luisa María Arvide Cambra

Affiliation: Department of Philology, University of Almeria, Spain.
Research Interest: Medieval Arabic Science, History of Medicine, Philological Studies, Humanities.

Prof. dr. habil. Mihail Lucian Birsa (002)

Prof. Mihail Lucian Birsa

Affiliation: Professor of Department of Chemistry, Alexandru Ioan Cuza University, Romania.
Research Interest: Medicinal Chemistry and Drug Design, Chemical Engineering, Modern Approaches in Drug Designing, Pharmaceutical Toxicology.

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Dr. Kalliopi Megari

Affiliation: Department of Neuropsychological, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Research Interest: Clinical Neuropsychology, Coronary Artery Bypass Surgery, Cognition Disorders, Heart Failure, Cardiac Surgery, Cognitive Neuropsychology, Cognitive Neuroscience, Memory, Executive Function, Cognitive Psychology.

LauraSarbu (002)

Prof. Laura Gabriela Sarbu

Affiliation: "Alexandru Ioan Cuza" University of Iasi, Faculty of Chemistry, Romania.
Research Interest: Organic Synthesis, Synthetic Drugs, Drug Design and Development, Cyclophanes, Flavonoids, Sulfur Compounds.

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Colonel Prof. Dr. med. Rainer Voisard

Affiliation: Clinical Director of Internal Medicine, Military Hospital Ulm, Germany.
Research Interest: Internal Medicine, Cardiology, Rehabilitation, Emergency Medicine.

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Prof. Ubaldo Comite

Affiliation: University of Calabria, Arcavacata – Rende, Italy.
Research Interest: Management, Public Administration, Accountancy, Health Management.

Article In Press

Authors:
Mohammad Ahmad Ahmad Odah*

Published Date: May 08, 2025

Cite: Odah MAA. Photosynthetic reprogramming enhancing carbon fixation in crops through synthetic biology. Crystal J Med Healthc. 2025;1(1): 01-10.

Abstract
Background: Photosynthesis is the foundation of plant productivity, yet its natural efficiency remains limited, with most staple crops operating under the suboptimal C3 pathway. Enhancing carbon fixation efficiency is a major goal in agricultural biotechnology, especially in the face of climate change and increasing food demands. Synthetic biology offers innovative strategies to reprogram photosynthesis, optimize RuBisCO function, and introduce synthetic carbon assimilation pathways.

Objective: This review explores the latest advancements in synthetic biology applied to photosynthetic reprogramming. It highlights the potential of genetic engineering to enhance carbon fixation, reduce photorespiration losses, and develop highyield, climate-resilient crops.

Methods: A comprehensive literature review was conducted, analyzing recent breakthroughs in RuBisCO optimization, synthetic carbon fixation cycles, and chloroplast genome engineering. Studies on engineered carbon-concentrating mechanisms (CCMs) and artificial CO₂ assimilation pathways were evaluated for their potential applications in agriculture.

Results: Synthetic biology approaches have demonstrated significant improvements in photosynthetic efficiency. Directed evolution has optimized RuBisCO activity, while the integration of bacterial and algal CCMs into C3 plants has increased CO₂ fixation rates. Additionally, synthetic pathways like the CETCH cycle show promise in surpassing the Calvin cycle’s efficiency.

Conclusion: The integration of synthetic biology into photosynthesis enhancement presents a transformative solution to improving crop productivity and climate resilience. While significant progress has been made, challenges remain in scaling these innovations to commercial agriculture. Future research should focus on refining metabolic engineering strategies, addressing regulatory concerns, and ensuring field applicability to maximize the impact of synthetic photosynthesis.


Keywords
Synthetic Biology, Photosynthetic Reprogramming, Carbon Fixation, RuBisCO Optimization, Climate-Resilient Crops, Metabolic Engineering

Authors: Mohammad Ahmad Ahmad Odah*

Published Date: April 30, 2025

Cite: Odah MAA. Mitochondrial epitranscriptomics: The role of RNA modifications in cellular energy regulation and aging. Crystal J Med Healthc. 2025;1(1): 01-08.

Abstract
Background: Mitochondria play a crucial role in cellular metabolism and energy production. While traditionally studied through nuclear and mitochondrial DNA regulation, recent research highlights the significance of post-transcriptional modifications in mitochondrial RNA (mtRNA). These modifications influence mitochondrial gene expression, energy balance, and aging. Understanding mitochondrial epitranscriptomics—specifically modifications like N6-methyladenosine (m6A), pseudouridylation, and 5-methylcytosine (m5C)—is essential for uncovering their impact on cellular function and disease.

Objective: This review aims to explore the emerging field of mitochondrial epitranscriptomics, analyzing key RNA modifications, their roles in oxidative phosphorylation (OXPHOS) and reactive oxygen species (ROS) regulation, and their implications in aging and age-related diseases. Additionally, we discuss advanced methodologies for studying these modifications and potential therapeutic strategies for mitochondrial dysfunction.

Conclusion: Mitochondrial RNA modifications represent a critical layer of gene regulation affecting cellular energy homeostasis and aging. Their dysregulation is associated with metabolic disorders, neurodegenerative diseases, and cellular senescence. Advances in RNA sequencing and epitranscriptomic research highlight the potential for therapeutic interventions targeting mitochondrial RNA modifications to mitigate mitochondrial dysfunction and promote longevity. A deeper understanding of these modifications could pave the way for novel approaches to treating age-related diseases and enhancing healthy aging.

Keywords
Mitochondrial Epitranscriptomics, RNA Modifications, Aging, Oxidative Phosphorylation, m6A, Pseudouridylation, m5C, Neurodegeneration, Metabolic Disorders, Longevity

Current Issue Articles

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Archive

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Guidelines for Authors

General Guidelines

  • Manuscripts must be original, unpublished, and not under consideration elsewhere.
  • Submissions must follow the specific formatting and structure requirements detailed below.
  • Authors are responsible for ensuring the accuracy and validity of their content, including citations, tables, and data.
  • Articles should be written in clear, concise, and grammatically correct English.
  • Include a cover letter detailing the significance of your work and how it contributes to the academic field.

Manuscript Preparation

Authors must ensure their manuscript is well-organized and follows the structure outlined below:

Format

  • File Type: Submit manuscripts in Microsoft Word format (.doc or .docx).
  • Font and Size: Use Times New Roman, 12-point font for the main text.
  • Line Spacing: Double-spaced.
  • Margins: 1-inch (2.54 cm) on all sides.

 

Structure

Manuscripts must be arranged in the following order:

Title Page

  • Title of the manuscript.
  • Full names of all authors, along with their affiliations.
  • The corresponding author’s name, email address, and phone number.
  • A running title (maximum 50 characters).

Abstract

  • Provide a concise summary of the study (150–250 words).
  • Highlight the research objective, methodology, key findings, and significance.
  • Include 4–6 relevant keywords.

Introduction

  • Clearly state the background, objectives, and significance of the study.

Headings, Subheadings, and Super Subheadings

  • After the Introduction, structure the manuscript using clear and appropriately labeled headings, subheadings, and super subheadings.
  • Use a logical numbering system to organize sections:
    • Heading: 1
    • Subheading: 1.1
    • Super Subheading: 1.1.1
  • Ensure each section is clearly distinguishable for better readability and logical flow.

Materials and Methods

  • Provide detailed information about the materials, tools, and methodologies used in the research to ensure reproducibility.

Results/Observations

  • Present the study’s findings clearly and concisely, supported by tables and figures where appropriate.

Discussion

  • Interpret the results in the context of existing research, highlighting their implications, limitations, and potential future directions.

Acknowledgments

  • Acknowledge funding sources, collaborators, or anyone who contributed to the research but does not meet authorship criteria.

References

  • List all cited sources in APA format.
  • Only published or accepted manuscripts should be included. Abstracts submitted to meetings but not yet accepted should not be cited.
  • For examples, refer to the Citation and References section below.

Books

  • Smith, J. (2020). Title of the book. Publisher Name.

Journal Articles

  • Doe, A., & Johnson, B. (2021). Title of the article. Journal Name, 10(2), 45–60. https://doi.org/xxxx

Conference Proceedings

  • Brown, C. (2022). Title of the paper. In D. Green (Ed.), Proceedings of the Conference Name (pp. 34–45). Publisher.

Websites

  • Author/Organization. (Year). Title of the webpage. Website URL.

Book Chapters

  • Taylor, L. (2021). Title of the chapter. In M. White (Ed.), Title of the book (pp. 45–60). Publisher.

 Tables

  • Submit tables in editable Word format, not as images or screenshots.
  • Provide clear and concise titles for each table.

Figures and Legends

  • Submit high-resolution figures separately in .PNG, .JPG, or .TIFF format (minimum 300 DPI).
  • Provide descriptive legends for each figure in the manuscript.

Submission Process

  • Submit manuscripts via the Crystal Scientific Publishers online submission portal or this email: Email: support@crystalscientificpublishers.com.
  • Include the following documents:
    • Manuscript file (Word format)
    • Cover letter detailing the significance of your work

 

Funding Statement

  • Authors must include a Funding Statement in their manuscript, specifying any financial support received for conducting the research or preparing the manuscript.

Fee Structure

  • Crystal Journal of Medical Research charges a nominal fee to cover processing, peer review, and publication costs.
  • Fees will be communicated upon submission. Discounts or waivers may be available in special cases.

By adhering to these guidelines, authors can ensure a smooth and efficient submission process. Thank you for contributing to the Crystal Journal of Medical Research, and for advancing the global pursuit of sustainability!